Dissecting rapid estrogen signaling with conjugates
نویسندگان
چکیده
منابع مشابه
Rapid estrogen signaling in the brain.
Estrogen has multiple actions in the brain to modulate homeostasis, synaptic plasticity/cognition and neuroprotection. While many of these actions undoubtedly involve mediation via the classical genomic mechanism of regulation of transcription of genes via estrogen nuclear receptors, there has been growing interest in the rapid nongenomic effects of estrogen and the role they may play in the ne...
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Estrogen receptors are best known as ligand-activated transcription factors that regulate vascular cell gene expression. For many years now, a rapid signaling pathway mediated by cell membrane-associated estrogen receptors also has been recognized, but the physiological relevance of this pathway has remained unclear. In this issue of the JCI, Chambliss et al. provide new data to indicate that a...
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The steroid hormone estrogen regulates many functionally unrelated processes in numerous tissues. Although it is traditionally thought to control transcriptional activation through the classical nuclear estrogen receptors, it also initiates many rapid nongenomic signaling events. We found that of all G protein-coupled receptors characterized to date, GPR30 is uniquely localized to the endoplasm...
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ble for the binding specificities of the semaphorins in situ (Feiner et al., 1997), while the Ig-basic domain also exhibits binding properties. The neuropilins have two N-terminal domains similar to complement binding domains , called CUB domains; two coagulation factor domains ; a C-terminal MAM domain; a transmembrane domain; and a short cytoplasmic tail (see figure). Both Giger et al. (1998)...
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BACKGROUND Clinical trial and epidemiological data support that the cardiovascular effects of estrogen are complex, including a mixture of both potentially beneficial and harmful effects. In animal models, estrogen protects females from vascular injury and inhibits atherosclerosis. These effects are mediated by estrogen receptors (ERs), which, when bound to estrogen, can bind to DNA to directly...
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ژورنال
عنوان ژورنال: Steroids
سال: 2012
ISSN: 0039-128X
DOI: 10.1016/j.steroids.2012.02.021